The RS1 Antibody (PAC029656) is a high-quality polyclonal antibody designed for research involving RS1, a protein involved in X-linked retinoschisis, a genetic eye disorder affecting males. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.RS1, also known as retinoschisin, plays a crucial role in maintaining the structural integrity of the retina by facilitating cell adhesion and signal transmission. Mutations in the RS1 gene lead to the development of retinoschisis, characterized by abnormal splitting of the retinal layers and reduced visual acuity.
The RS1 Antibody enables researchers to detect and analyze RS1 protein expression in retinal cells, aiding in the understanding of the disease mechanisms and potential therapeutic targets.The RS1 Antibody is a valuable tool for studying X-linked retinoschisis and related retinal diseases, providing insights into the pathophysiology and potential treatment options. Its specificity and sensitivity make it an ideal choice for researchers in the fields of ophthalmology, genetics, and molecular biology looking to further unravel the complexities of retinal disorders.
Antibody Name:
RS1 Antibody (PACO29656)
Antibody SKU:
PACO29656
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Retinoschisin protein (24-224AA)
Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009).
UniProt Protein Details:
NCBI Summary:
This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008]
