The SEC14L3 Polyclonal Antibody (PAC042038) is designed for research involving SEC14L3, a protein involved in lipid metabolism and intracellular trafficking. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunofluorescence. It binds to the SEC14L3 protein, allowing for the detection and analysis of this important molecule in different cell types.SEC14L3 is known to play a crucial role in lipid transfer and signaling pathways within cells, making it a key player in the regulation of cellular processes such as membrane trafficking and lipid metabolism.
Studies have shown that dysregulation of SEC14L3 can lead to various diseases including metabolic disorders and cancer. Therefore, understanding the function of SEC14L3 is essential for developing targeted therapies and interventions in these disease contexts.Overall, the SEC14L3 Polyclonal Antibody is a valuable tool for researchers interested in studying the role of SEC14L3 in cellular processes and disease pathology, making it an ideal choice for immunology, lipid metabolism, and cancer research studies.
Western Blot. Positive WB detected in: Mouse liver tissue, Mouse lung tissue. All lanes: SEC14L3 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO42038 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO42038 at dilution of 1:100.
Background:
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
Synonyms:
SEC14-like protein 3 (Tocopherol-associated protein 2), SEC14L3, TAP2
UniProt Protein Function:
SEC14L3: Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.Chromosomal Location of Human Ortholog: 22q12.2Cellular Component: integral to membrane; intracellularMolecular Function: lipid binding; transporter activityBiological Process: transport
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
