The SEC24A Antibody (PACO12083) is a polyclonal antibody specifically designed for research involving SEC24A, a key component of the COPII coat involved in vesicle trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus. This antibody is raised in rabbits and is highly reactive with human samples, making it suitable for various applications including Western blotting.SEC24A plays a crucial role in the secretory pathway, ensuring the proper transport of cargo proteins from the ER to the Golgi for further processing and sorting. Dysregulation of SEC24A has been implicated in various cellular processes and disease conditions, making it a valuable target for research in cell biology and related fields.
By targeting the SEC24A protein, this antibody enables researchers to study the function and regulation of COPII-mediated vesicle trafficking, shedding light on the mechanisms underlying cellular homeostasis and disease pathology. Its versatility in different cell types and applications makes it an essential tool for studies in molecular biology and drug discovery aimed at understanding and targeting the secretory pathway.
SEC24A: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2. Expressed in fibroblasts, hepatocytes, and lymphocytes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q31.1Cellular Component: cytosol; endoplasmic reticulum membraneMolecular Function: protein bindingBiological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
