The SEMA6A Polyclonal Antibody (PAC051074) is specifically designed for researchers studying SEMA6A, a cell surface protein known for its role in axon guidance and immune regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the SEMA6A protein, this antibody enables accurate detection and analysis in various cell types, making it an excellent tool for immunology and neuroscience research.
SEMA6A, a member of the semaphorin family, is involved in regulating neuronal development and immune responses. Its function in mediating axon guidance and modulating immune signaling pathways makes it a promising target for investigating neurological disorders, autoimmune diseases, and cancer. Understanding the mechanisms by which SEMA6A influences these processes is essential for developing targeted therapies and interventions in these areas of study.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO51074 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO51074 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).
SEMA6A: a single-pass type I membrane protein of the semaphorin family that can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Active as a homodimer or oligomer. Interacts with EVL. Two isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 5q23.1Cellular Component: integral to plasma membraneMolecular Function: chemorepellent activity; protein binding; semaphorin receptor bindingBiological Process: negative regulation of axon extension involved in axon guidance; neural crest cell migration
UniProt Protein Details:
NCBI Summary:
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
