The SLC37A1 Polyclonal Antibody (PAC04766) is a valuable tool for researchers studying SLC37A1, a crucial protein involved in glucose and phosphate metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the SLC37A1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in metabolic disorders and related research fields.SLC37A1, also known as glucose-6-phosphate transporter 1, plays a key role in the transport of glucose-6-phosphate into the lumen of the endoplasmic reticulum, contributing to glucose homeostasis and cellular energy balance.
Dysregulation of SLC37A1 has been linked to metabolic disorders such as glycogen storage disease and type 2 diabetes, making it a promising target for therapeutic interventions aimed at restoring normal metabolic function.By utilizing the SLC37A1 Polyclonal Antibody in your research, you can gain valuable insights into the function and regulation of SLC37A1, paving the way for novel approaches to treat metabolic disorders and improve overall health outcomes.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO47666 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO47666 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO47666 at dilution of 1:100.
Background:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
Synonyms:
Glucose-6-phosphate exchanger SLC37A1 (Glycerol-3-phosphate permease) (G-3-P permease) (Solute carrier family 37 member 1), SLC37A1, G3PP
UniProt Protein Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
