The STEAP2 Polyclonal Antibody (PAC023268) is a valuable tool for researchers studying the STEAP2 protein, a member of the six-transmembrane epithelial antigen of the prostate (STEAP) family. This antibody, generated in rabbits, is particularly reactive with human samples and has been extensively validated for use in Western blot applications. By specifically binding to the STEAP2 protein, this antibody allows for accurate detection and analysis in various cell types, making it an ideal choice for studies in cancer research and immunology.
STEAP2 is known for its role in iron metabolism and its potential involvement in cancer progression. Understanding the function of STEAP2 is crucial for unraveling its significance in disease development and progression, particularly in cancer. By targeting STEAP2 with this polyclonal antibody, researchers can gain insights into its mechanisms of action and explore potential therapeutic interventions for cancer and other related conditions.
Synthesized peptide derived from C-terminal of human STEA2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using STEA2 antibody.
Immunofluorescence analysis of A549 cells, using STEA2 antibody.
Background:
Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor By similarity.
Synonyms:
EC 1.16.1.-; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1; Prostate cancer-associated protein 1;
UniProt Protein Function:
STEAP2: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.16.1.-; Membrane protein, integral; Vesicle; Membrane protein, multi-passChromosomal Location of Human Ortholog: 7q21.13Cellular Component: trans-Golgi network transport vesicle; intracellular membrane-bound organelle; early endosome; plasma membrane; integral to Golgi membrane; endosome membrane; cytosolMolecular Function: transporter activity; metal ion binding; cupric reductase activityBiological Process: regulated secretory pathway; Golgi to plasma membrane transport; iron ion homeostasis; response to hormone stimulus; copper ion import; endocytosis
UniProt Protein Details:
NCBI Summary:
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
