Anti-TRPM8 Antibody (CAB4269)

SKU:
CAB4269
€129 - €349

Description

Technical Manual

Anti-TRPM8 Antibody

Product Name:Anti-TRPM8 Antibody
Product SKU:CAB4269
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:
Immunogen:A synthesized peptide derived from human TRPM8
Sequence:

Email for sequence

Gene ID:79054
Swiss Prot:Q7Z2W7
Synonyms:LTRPC6; TRPP8
Calculated MW:128kDa
Observed MW:110KDa
Reactivity:Human
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting
Positive Samples:PC-3, MCF7
Cellular Location:

Product Images

Anti-TRPM8 Antibody (CAB4269)

Western blot - TRPM8 Rabbit mAb (CAB4269)

Uniprot Information

UniProt Protein Function:TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Channel, cation; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: plasma membrane

Molecular Function:calcium channel activity; protein binding

UniProt Code:Q7Z2W7
NCBI GenInfo Identifier:143811469
NCBI Gene ID:79054
NCBI Accession:Q7Z2W7.2
UniProt Secondary Accession:Q7Z2W7,Q3YFM7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1, A0AVG2
UniProt Related Accession:Q7Z2W7
Molecular Weight:79,096 Da
NCBI Full Name:Transient receptor potential cation channel subfamily M member 8
NCBI Synonym Full Names:transient receptor potential cation channel subfamily M member 8
NCBI Official Symbol:TRPM8
NCBI Official Synonym Symbols:TRPP8; LTRPC6
NCBI Protein Information:transient receptor potential cation channel subfamily M member 8
UniProt Protein Name:Transient receptor potential cation channel subfamily M member 8
UniProt Synonym Protein Names:Long transient receptor potential channel 6; LTrpC-6; LTrpC6; Transient receptor potential p8; Trp-p8
Protein Family:TRPM8 channel-associated factor
UniProt Gene Name:TRPM8
UniProt Entry Name:TRPM8_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
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