The ANG1 Polyclonal Antibody (PACO33500) is a valuable tool for researchers studying Angiopoietin-1 (ANG1), a protein involved in angiogenesis and vascular stabilization. This antibody is raised in rabbits and has high reactivity with human samples, making it suitable for use in Western blot applications. ANG1 is known for its role in promoting blood vessel formation and regulating vascular permeability. Research into ANG1 has implications for various fields, including cancer research, cardiovascular disease, and wound healing.
By utilizing the ANG1 Polyclonal Antibody, researchers can detect and analyze the expression of ANG1 in different cell types, furthering our understanding of its function in physiological and pathological processes. With its proven specificity and sensitivity, the ANG1 Polyclonal Antibody is a valuable tool for investigating the role of ANG1 in health and disease, ultimately contributing to the development of new therapeutic strategies targeting angiogenesis and vascular function.
Antibody Name:
ANG1 Antibody (PACO33500)
Antibody SKU:
PACO33500
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Bovine
Immunogen:
Recombinant Bovine Angiogenin-1 protein (24-148AA)
May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.
Synonyms:
Angiogenin-1 (EC 3.1.27.-), ANG1, ANG
UniProt Protein Function:
Function: Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) By similarity. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity.Subunit structure: Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur By similarity.Subcellular location: Secreted extracellular space extracellular matrix basement membrane. Nucleus nucleolus By similarity. Note: Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA By similarity.Tissue specificity: Serum and milk.Sequence similarities: Belongs to the pancreatic ribonuclease family.
