The CALR Polyclonal Antibody (PAC057688) is a valuable tool for research studies involving CALR, a chaperone protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, produced in rabbits, is highly specific to human samples and has been extensively validated for Western blot applications. By binding to the CALR protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in the fields of molecular biology and cancer research.CALR, also known as calreticulin, is a multifunctional protein with diverse roles in cellular processes including calcium homeostasis, cell adhesion, and antigen presentation.
Dysregulation of CALR has been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative conditions. Understanding the functions of CALR is important for uncovering potential therapeutic targets and developing interventions for these diseases.In conclusion, the CALR Polyclonal Antibody is a reliable tool for researchers studying the functions and implications of CALR in different cellular contexts. Its high specificity and sensitivity make it a valuable asset for advancing scientific understanding in areas such as cancer biology, immunology, and cell biology.
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.
