Human NPPC Recombinant Protein (RPPB0810)
- SKU:
- RPPB0810
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P23582
- Research Area:
- Cytokines
Description
| Product Name: | Human NPPC Recombinant Protein |
| Product Code: | RPPB0810 |
| Size: | 20µg |
| Species: | Human |
| Target: | NPPC |
| Synonyms: | Natriuretic Peptide Precursor C, C-Type Natriuretic Peptide, CNP2, CNP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The NPPC solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSKPGAPPK VPRTPPAEEL AEPQAAGGGQ KKGDKAPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS MSGLGC |
NPPC is proteolytically managed to create a secreted hormone of the natriuretic peptide family. NPPC is vasoactive and natriuretic and controls the evolution and differentiation of cartilaginous growth plate chondrocytes.
NPPC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 126 amino acids (24-126) and having a molecular mass of 13.2kDa.NPPC is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Hormone; Secreted Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: extracellular region Molecular Function:receptor binding Biological Process: cGMP biosynthetic process; negative regulation of meiotic cell cycle; receptor guanylyl cyclase signaling pathway; regulation of cAMP metabolic process; regulation of cGMP metabolic process |
| NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P23582 |
| NCBI GenInfo Identifier: | 113850 |
| NCBI Gene ID: | 4880 |
| NCBI Accession: | P23582.1 |
| UniProt Secondary Accession: | P23582,Q4ZG41, |
| UniProt Related Accession: | P23582 |
| Molecular Weight: | 13,246 Da |
| NCBI Full Name: | C-type natriuretic peptide |
| NCBI Synonym Full Names: | natriuretic peptide C |
| NCBI Official Symbol: | NPPC�� |
| NCBI Official Synonym Symbols: | CNP; CNP2�� |
| NCBI Protein Information: | C-type natriuretic peptide |
| UniProt Protein Name: | C-type natriuretic peptide |
| Protein Family: | C-type natriuretic peptide |
| UniProt Gene Name: | NPPC�� |
| UniProt Entry Name: | ANFC_HUMAN |
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