Description
| Product Name: | Human RBM11 Recombinant Protein |
| Product Code: | RPPB4421 |
| Size: | 20µg |
| Species: | Human |
| Target: | RBM11 |
| Synonyms: | Splicing regulator RBM11, RNA-binding motif protein 11, RBM11. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The RBM11 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMFPAQEE ADRTVFVGNL EARVREEILY ELFLQAGPLT KVTICKDREG KPKSFGFVCF KHPESVSYAI ALLNGIRLYG RPINVQYRFG SSRSSEPANQ SFESCVKINS HNYRNEEMLV GRSSFPMQYF PINNTSLPQE YFLFQKMQWH VYNPVLQLPY YEMTAPLPNS ASVSSSLNHV PDLEAGPSSY KWTHQQPSDS DLYQMTAPLP NSASVSSSLN HVPDLEAGPS SYKWTHQQPS DSDLYQMNKR KRQKQTSDSD SSTDNNRGNE CSQKFRKSKK KKRY |
RNA Binding Motif Protein 11 (RBM11) which contains 1 RNA recognition motif is a part of the RBM family. The RBM gene family encodes proteins with an RNA binding motif which participate in the modulation of apoptosis. RBM11 is expressed in testis, kidney, spleen, brain, spinal cord and mammary gland and can be found as 2 isoforms produced by alternative splicing.��
RBM11 Human Recombinant produced in E. coli is a single polypeptide chain containing 304 amino acids (1-281) and having a molecular mass of 34.6kDa. RBM11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RBM11: Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 21q11 Cellular Component: nuclear speck; nucleoplasm; nucleus Molecular Function:poly(U) binding; protein binding; protein homodimerization activity Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome |
| UniProt Code: | P57052 |
| NCBI GenInfo Identifier: | 9978670 |
| NCBI Gene ID: | 54033 |
| NCBI Accession: | P57052.1 |
| UniProt Secondary Accession: | P57052,Q6YNC2, Q8NBA1, Q8NFF6, |
| UniProt Related Accession: | P57052 |
| Molecular Weight: | 26,465 Da |
| NCBI Full Name: | Splicing regulator RBM11 |
| NCBI Synonym Full Names: | RNA binding motif protein 11 |
| NCBI Official Symbol: | RBM11�� |
| NCBI Protein Information: | splicing regulator RBM11 |
| UniProt Protein Name: | Splicing regulator RBM11 |
| UniProt Synonym Protein Names: | RNA-binding motif protein 11 |
| Protein Family: | Splicing regulator |
| UniProt Gene Name: | RBM11�� |
| UniProt Entry Name: | RBM11_HUMAN |
