Human UBXN2B Recombinant Protein (RPPB5073)
- SKU:
- RPPB5073
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q14CS0
Frequently bought together:
Description
| Product Name: | Human UBXN2B Recombinant Protein |
| Product Code: | RPPB5073 |
| Size: | 10µg |
| Species: | Human |
| Target: | UBXN2B |
| Synonyms: | UBX domain-containing protein 2B, p37, NSFL1 cofactor p37, p97 cofactor p37, UBXN2B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The UBXN2B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAEGGGP EPGEQERRSS GPRPPSARDL QLALAELYED EVKCKSSKSN RPKATVFKSP RTPPQRFYSS EHEYSGLNIV RPSTGKIVNE LFKEAREHGA VPLNEATRAS GDDKSKSFTG GGYRLGSSFC KRSEYIYGEN QLQDVQILLK LWSNGFSLDD GELRPYNEPT NAQFLESVKR GEIPLELQRL VHGGQVNLDM EDHQDQEYIK PRLRFKAFSG EGQKLGSLTP EIVSTPSSPE EEDKSILNAV VLIDDSVPTT KIQIRLADGS RLIQRFNSTH RILDVRNFIV QSRPEFAALD FILVTSFPNK ELTDESLTLL EADILNTVLL QQLK |
UBX Domain Protein 2B (UBXN2B) is a 331 amino acid protein which comprises one UBX domain and one SEP domain. UBXN2B is essential for ER and Golgi biogenesis and also takes a place in their maintenance during interphase, as well as their reassembly at the end of mitosis. Through interaction with VCP, UBXN2B forms a complex that has membrane fusion activity.
UBXN2B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 354 amino acids (1-331) and having a molecular mass of 39.5 kDa. UBXN2B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UBXN2B: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Belongs to the NSFL1C family.Protein type: Adaptor/scaffold; Endoplasmic reticulumChromosomal Location of Human Ortholog: 8q12.1Cellular Component: Golgi apparatus; endoplasmic reticulum; cytosol; nucleusMolecular Function: ubiquitin binding; protein phosphatase type 1 regulator activityBiological Process: proteasomal ubiquitin-dependent protein catabolic process; regulation of catalytic activity; nuclear envelope reassembly; Golgi organization and biogenesis; autophagic vacuole formation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q14CS0 |
| NCBI GenInfo Identifier: | 121946691 |
| NCBI Gene ID: | 137886 |
| NCBI Accession: | Q14CS0.1 |
| UniProt Secondary Accession: | Q14CS0,B3KWZ3 |
| UniProt Related Accession: | Q14CS0 |
| Molecular Weight: | 37,077 Da |
| NCBI Full Name: | UBX domain-containing protein 2B |
| NCBI Synonym Full Names: | UBX domain protein 2B |
| NCBI Official Symbol: | UBXN2B�� |
| NCBI Official Synonym Symbols: | p37�� |
| NCBI Protein Information: | UBX domain-containing protein 2B; p97 cofactor p37; NSFL1 cofactor p37 |
| UniProt Protein Name: | UBX domain-containing protein 2B |
| UniProt Synonym Protein Names: | NSFL1 cofactor p37; p97 cofactor p37 |
| Protein Family: | UBX domain-containing protein |
| UniProt Gene Name: | UBXN2B�� |
| UniProt Entry Name: | UBX2B_HUMAN |
