The KATNB1 Polyclonal Antibody is specifically designed for research involving KATNB1, a protein involved in microtubule organization and cell division. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunofluorescence.KATNB1 is a key regulator of microtubule dynamics and plays a critical role in cell division and migration. Dysregulation of KATNB1 has been implicated in various diseases, including cancer and neurological disorders.
By targeting KATNB1, researchers can gain insights into its functions and potential therapeutic applications in these diseases.This antibody enables the detection and analysis of KATNB1 in various cell types, making it an ideal tool for researchers in cell biology, cancer biology, and neurology. Understanding the role of KATNB1 in cellular processes is essential for advancing our knowledge of disease mechanisms and developing targeted therapies.
Product Name:
KATNB1 Polyclonal Antibody
SKU:
CAB21041
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human KATNB1 (NP_005877.2).
Sequence:
SEPF PAPP EDDA ATAK EAAK PSPA MDVQ FPVP NLEV LPRP PVVA STPA PKAE PAII PATR NEPI GLKA SDFL PAVK IPQQ AELV DEDA MSQI RKGH DTMC V
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.
Purification Method:
Affinity purification
Gene ID:
10300
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KATNB1 antibody (CAB21041) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
