The KLHL21 Polyclonal Antibody (PAC010135) is a high-quality research tool specifically designed for studying KLHL21, a protein involved in ubiquitination processes and cellular regulation. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the KLHL21 protein, researchers can accurately detect and analyze its presence in various cell types, providing valuable insights into its function in cellular processes.KLHL21 is a key player in ubiquitin-mediated protein degradation pathways, regulating the turnover of important cellular proteins.
Its role in cellular regulation makes it a promising target for research in various fields, including cancer biology, neurodegenerative diseases, and developmental biology. Understanding the functions and mechanisms of KLHL21 is essential for uncovering its potential therapeutic applications and implications in disease pathology.By utilizing the KLHL21 Polyclonal Antibody (PAC010135), researchers can further investigate the role of KLHL21 in cellular processes and disease states, ultimately advancing our understanding of this important protein and its implications in human health and disease.
KLHL21: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 1p36.31Cellular Component: centrosome; cytoplasm; polar microtubuleMolecular Function: ubiquitin-protein ligase activityBiological Process: mitosis; cell division; protein ubiquitination; regulation of cytokinesis
