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NGF Antibody (PACO02230)

SKU:
PACO02230
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Application:
WB
Antibody type:
Polyclonal
Conjugation:
Unconjugated
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Description

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Antibody Name:NGF Antibody
Antibody SKU:PACO02230
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human NGF.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:NGF; NGFB; Beta-nerve growth factor; Beta-NGF
UniProt Protein Function:NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: cytoplasmic membrane-bound vesicle; endosome; extracellular region; Golgi lumen

Molecular Function:growth factor activity; metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding; receptor signaling protein activity

Biological Process: activation of MAPKK activity; cell-cell signaling; induction of apoptosis via death domain receptors; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of neuron apoptosis; nerve growth factor processing; nerve growth factor receptor signaling pathway; neurite morphogenesis; neuron apoptosis; peripheral nervous system development; phosphoinositide-mediated signaling; phospholipase C activation; positive regulation of apoptosis; positive regulation of axon extension; positive regulation of axonogenesis; positive regulation of collateral sprouting; positive regulation of neuron maturation; positive regulation of protein ubiquitination; Ras protein signal transduction; regulation of axonogenesis; regulation of caspase activity; regulation of neuron differentiation; regulation of neurotransmitter secretion; regulation of release of sequestered calcium ion into cytosol; sensory perception of pain; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V

NCBI Summary:This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
UniProt Code:P01138
NCBI GenInfo Identifier:90110037
NCBI Gene ID:4803
NCBI Accession:P01138.3
UniProt Secondary Accession:P01138,Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8, A1A4E5,
UniProt Related Accession:P01138
Molecular Weight:26,959 Da
NCBI Full Name:Beta-nerve growth factor
NCBI Synonym Full Names:nerve growth factor
NCBI Official Symbol:NGF  
NCBI Official Synonym Symbols:NGFB; HSAN5; Beta-NGF  
NCBI Protein Information:beta-nerve growth factor
UniProt Protein Name:Beta-nerve growth factor
Protein Family:Nerve growth factor
UniProt Gene Name:NGF  
UniProt Entry Name:NGF_HUMAN

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