Rat Eotaxin 2 Recombinant Protein (RPPB1129)
- SKU:
- RPPB1129
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- Q5PPP2
- Research Area:
- Chemokines
Description
| Product Name: | Rat Eotaxin 2 Recombinant Protein |
| Product Code: | RPPB1129 |
| Size: | 20µg |
| Species: | Rat |
| Target: | Eotaxin 2 |
| Synonyms: | C-C motif chemokine 24, Small-inducible cytokine A24, Myeloid progenitor inhibitory factor 2, CK-beta-6, Eosinophil chemotactic protein 2, Eotaxin-2, CCL24, Ckb-6, MPIF2, MPIF-2, SCYA24, Eotaxin2, CCL-24. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized CCL24�Rat Recombinant in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Eotaxin-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL24 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | VTIPSSCCVT FISKKIPVNR VISYQLANGS ICPKAGVIFI TKKGHKICTD PKLPWVQKHI KNLDAKRNQP SEGAKALGPK FVIQKLRGNS TKV |
| Biological Activity: | Determined by its ability to chemoattract murine lymphocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. |
Eotaxin-2, also called MPIF2 & Ckb6, is a novel CC chemokine produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Furthermore, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which includes C-terminal truncation, contains 78 amino acids (92 amino acids for the mouse homolog, without C-terminal truncation).CCL24 functions as a chemotactic chemokine for resting t-lymphocytes, and eosinophils. CCL24 has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line and binds to CCR3.
CCL24 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids and having a molecular mass of 10.2kDa. The CCL24 is purified by proprietary chromatographic techniques.
| UniProt Code: | Q5PPP2 |
| NCBI GenInfo Identifier: | 61556786 |
| NCBI Gene ID: | 288593 |
| NCBI Accession: | NP_001013063.1 |
| Molecular Weight: | 10.5 kd |
| NCBI Full Name: | C-C motif chemokine 24 |
| NCBI Synonym Full Names: | C-C motif chemokine ligand 24 |
| NCBI Official Symbol: | Ccl24�� |
| NCBI Protein Information: | C-C motif chemokine 24 |
| UniProt Protein Name: | C-C motif chemokine ligand 24 |
| UniProt Synonym Protein Names: | C-C motif chemokine ligand 24 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | Ccl24�� |
