The RBM38 Polyclonal Antibody (PAC052818) is a valuable tool for researchers studying RBM38, a RNA-binding protein involved in post-transcriptional regulation of gene expression. This antibody, generated in rabbits, is highly specific for RBM38 in human samples and is validated for use in Western blot applications. By binding to RBM38, researchers can detect and analyze its expression in various cell types, making it ideal for studies in molecular biology and cancer research.RBM38, also known as RNPC1, is a key player in mRNA stability and alternative splicing, affecting the expression of genes involved in cell proliferation, apoptosis, and differentiation. Dysregulation of RBM38 has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions.
Understanding the role of RBM38 in gene regulation is essential for developing targeted treatments for cancer and other illnesses.Overall, the RBM38 Polyclonal Antibody is a reliable tool for investigating the functions of RBM38 in gene expression and identifying potential therapeutic strategies for diseases associated with its dysregulation. Its high specificity and validated performance in Western blot assays make it a valuable addition to any research laboratory interested in studying RNA-binding proteins and their impact on cellular processes.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO52818 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO52818 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
Synonyms:
RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4), RBM38, RNPC1 SEB4
UniProt Protein Function:
CDH4: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Expressed mainly in brain but also found in other tissues.Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 20q13.3Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: heterophilic cell adhesion; axon guidance; intercellular junction assembly and maintenance; positive regulation of axon extension; cell adhesion; homophilic cell adhesion
