Human BLVRA Recombinant Protein (RPES3440)

SKU:
RPES3440
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
€303

Description

ELISA Kit Technical Manual

Recombinant Human BLVRA Protein (His Tag)

Background:Human Biliverdin reductase A (BLVRA) is belonged to the Gfo/Idh/MocA family and Biliverdin reductase subfamily. BLVRA is an enzyme that in humans is encoded by the BLVRA gene. BLVRA plays an important role in reducing the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. BLVRA acts on biliverdin by reducing its double-bond between the pyrrole rings into a single-bond. It accomplishes this using NADPH + H+ as an electron donor, forming bilirubin and NADP+ as products.
Name:Recombinant Human BLVRA Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES3440
Synonyms:BLVRA;Biliverdin reductase A;BVR A;Biliverdin-IX alpha-reductase;BLVR;BVR
Species:Human
Expression host:E.coli
Sequence:Glu6-Ser294
Accession:P53004
Mol Mass:33.8 kDa
AP Mol Mass:40 kDa
Tag:C-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM Tris,150mM NaCl,0.05% Brij35,20%Glycerol,pH 8.0.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:BVR: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Monomer. Liver. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
UniProt Protein Details:

Protein type:Oxidoreductase; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; ATYPICAL group; BLVRA family

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytosol

Molecular Function:zinc ion binding; biliverdin reductase activity

Biological Process: heme catabolic process; porphyrin metabolic process

Disease: Hyperbiliverdinemia

NCBI Summary:The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:P53004
NCBI GenInfo Identifier:23830892
NCBI Gene ID:644
NCBI Accession:P53004.2
UniProt Related Accession:P53004
Molecular Weight:
NCBI Full Name:Biliverdin reductase A
NCBI Synonym Full Names:biliverdin reductase A
NCBI Official Symbol:BLVRA  
NCBI Official Synonym Symbols:BVR; BLVR; BVRA  
NCBI Protein Information:biliverdin reductase A
UniProt Protein Name:Biliverdin reductase A
UniProt Synonym Protein Names:Biliverdin-IX alpha-reductase
UniProt Gene Name:BLVRA  
UniProt Entry Name:BIEA_HUMAN
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