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Human ERN1/IRE1 Recombinant Protein (RPES1048)

SKU:
RPES1048
Product type:
Recombinant Protein
Host species:
Baculovirus-Insect Cells
Reactivity:
Human
€626
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Description

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Human ERN1/IRE1 Recombinant Protein

The encoded protein contains two functional catalytic domains; a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins; regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.