Recombinant Human LTBR/TNFRSF3 Protein (Fc Tag) (RPES3867)



ELISA Kit Technical Manual

Recombinant Human LTBR/TNFRSF3 Protein (Fc Tag)

Background:Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,TNFCR, TNFR3 and TNFRSF3, is a member of the tumor necrosis factor (TNF) family of receptors. LTBR is a single-pass type I membrane protein and contains four TNFR-Cys repeats. It is expressed on the surface of most cell types, but not on T and B lymphocytes. LTBR and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of LTBR can trigger apoptosis. In addition, LTBR can lead to the release of the cytokine interleukin 8.
Name:Recombinant Human LTBR/TNFRSF3 Protein (Fc Tag)
Assay Genie SKU:RPES3867
Synonyms:Tumor Necrosis Factor Receptor Superfamily Member 3; Lymphotoxin-Beta Receptor; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor 2-Related Protein; Tumor Necrosis Factor Receptor Type III; TNF-RIII; TNFR-III; LTBR; D12S370; TNFCR; TNFR3; TNFRSF3
Expression host:Human Cells
Mol Mass:48.8 kDa
AP Mol Mass:61 kDa
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to membrane

Molecular Function:identical protein binding; protein binding; ubiquitin protein ligase binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; positive regulation of JNK cascade; myeloid dendritic cell differentiation; signal transduction

NCBI Summary:This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
UniProt Code:P36941
NCBI GenInfo Identifier:549090
NCBI Gene ID:4055
NCBI Accession:P36941.1
UniProt Secondary Accession:P36941,B7Z1D2, D3DUR2, F5GXE7,
UniProt Related Accession:P36941
Molecular Weight:435
NCBI Full Name:Tumor necrosis factor receptor superfamily member 3
NCBI Synonym Full Names:lymphotoxin beta receptor (TNFR superfamily, member 3)
NCBI Official Symbol:LTBR
NCBI Official Synonym Symbols:CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III
NCBI Protein Information:tumor necrosis factor receptor superfamily member 3; lymphotoxin B receptor; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 3
UniProt Synonym Protein Names:Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:LTBR
UniProt Entry Name:TNR3_HUMAN
View AllClose

Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
View AllClose