null

Human PTH1R Recombinant Protein (RPES1209)

SKU:
RPES1209
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
€129
Frequently bought together:

Description

system_update_altDatasheet

Human PTH1R Recombinant Protein

Parathyroid hormone 1 receptor(PTH1R) is a multi-pass membrane protein. The protein is expressed in high levels in bone and kidney and regulates calcium ionhomeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. This turns on osteoclasts to ultimately increase the resorption rate.