Recombinant Human Vaspin/SerpinA12 Protein (GST Tag) (RPES5075)

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SKU:
RPES5075
€303

Description

ELISA Kit Technical Manual

Recombinant Human Vaspin/SerpinA12 Protein (GST Tag)

Background:Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three ?-sheets, nine ?-helices, and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.
Name:Recombinant Human Vaspin/SerpinA12 Protein (GST Tag)
Size:10µg
Assay Genie SKU:RPES5075
Synonyms:Serpin A12; OL-64; Visceral Adipose Tissue-Derived Serine Protease Inhibitor; Vaspin; Visceral Adipose-Specific Serpin; SERPINA12
Species:Human
Expression host:E.coli
Sequence:Leu21-Lys414
Accession:Q8IW75
Mol Mass:71.4 kDa
AP Mol Mass:72 kDa
Tag:N-GST
Purity:> 90% as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per ?g as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 50mM TrisHCl, 160mM NaCl, 0.2mM PMSF, 1mM DTT, 10% Glycerine, pH 7.2 .
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:SERPINA12: May modulate insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. Belongs to the serpin family.
UniProt Protein Details:

Protein type:Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: extracellular space; plasma membrane

Molecular Function:serine-type endopeptidase inhibitor activity

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; negative regulation of lipid biosynthetic process; negative regulation of gluconeogenesis; positive regulation of insulin receptor signaling pathway

UniProt Code:Q8IW75
NCBI GenInfo Identifier:74728144
NCBI Gene ID:145264
NCBI Accession:Q8IW75.1
UniProt Related Accession:Q8IW75
Molecular Weight:47,175 Da
NCBI Full Name:Serpin A12
NCBI Synonym Full Names:serpin peptidase inhibitor, clade A (alpha antiproteinase, antitrypsin), member 12
NCBI Official Symbol:SERPINA12  
NCBI Official Synonym Symbols:OL-64  
NCBI Protein Information:serpin A12; vaspin; visceral adipose-specific SERPIN; visceral adipose tissue-derived serine protease inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha antiproteinase, antitrypsin), member 12
UniProt Protein Name:Serpin A12
UniProt Synonym Protein Names:OL-64; Visceral adipose tissue-derived serine protease inhibitor; Vaspin; Visceral adipose-specific serpin
Protein Family:Serpin
UniProt Gene Name:SERPINA12  
UniProt Entry Name:SPA12_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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