The SLC19A2 Polyclonal Antibody (PACO14998) is a valuable tool for researchers studying SLC19A2, a key protein involved in cellular folate transport and metabolism. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the SLC19A2 protein, this antibody enables precise detection and analysis in various cell types, facilitating investigations in fields such as molecular biology, pharmacology, and cancer research.
SLC19A2, also known as the reduced folate carrier 1 (RFC1), is essential for the uptake of folates required for DNA synthesis and repair, making it a crucial player in cell proliferation and growth. Dysregulation of SLC19A2 has been implicated in various diseases, including cancer, neurological disorders, and developmental abnormalities. Therefore, exploring the functions and mechanisms of SLC19A2 using this antibody is vital for uncovering potential therapeutic targets and treatment strategies for these conditions.
Antibody Name:
SLC19A2 Antibody (PACO14998)
Antibody SKU:
PACO14998
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human SLC19A2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14998(SLC19A2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness.
Synonyms:
solute carrier family 19 (thiamine transporter), member 2
UniProt Protein Function:
SLC19A2: High-affinity transporter for the intake of thiamine. Defects in SLC19A2 are the cause of thiamine-responsive megaloblastic anemia syndrome (TRMA); also known as Rogers syndrome. TRMA is an autosomal recessive disease with features that include megaloblastic anemia, mild thrombocytopenia and leucopenia, sensorineural deafness and diabetes mellitus. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q23.3Cellular Component: integral to membrane; plasma membraneMolecular Function: folic acid transporter activity; protein binding; thiamin transmembrane transporter activity; thiamin uptake transmembrane transporter activityBiological Process: vitamin metabolic process; thiamin and derivative metabolic process; thiamin transport; water-soluble vitamin metabolic process; folic acid transportDisease: Thiamine-responsive Megaloblastic Anemia Syndrome
UniProt Protein Details:
NCBI Summary:
This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. [provided by RefSeq, Jul 2008]
