The SSH3 Polyclonal Antibody (PACO12475) is a valuable tool for researchers studying the SSH3 protein, a key player in cell migration and invasion processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SSH3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell biology and cancer research.
SSH3, also known as cofilin-2, is involved in actin dynamics and plays a crucial role in cell motility and invasion. Its function in promoting cell migration has significant implications in cancer metastasis, making it a potential target for therapeutic interventions. By understanding the mechanisms by which SSH3 regulates cell movement, researchers can develop novel strategies for inhibiting cancer spread and improving patient outcomes.
SSH3: a protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Does not bind to, or colocalize with, filamentous actin. Five alternatively spliced isoforms have been described.Protein type: Cytoskeletal; EC 3.1.3.16; Protein phosphatase, dual-specificity; Phosphatase; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: 11q13.2Cellular Component: cytoplasmMolecular Function: actin bindingBiological Process: regulation of actin polymerization and/or depolymerization; regulation of axonogenesis
UniProt Protein Details:
NCBI Summary:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
