The ST8SIA3 Monoclonal Antibody (PAC012496) is a valuable tool for researchers studying ST8SIA3, a key enzyme involved in the synthesis of polysialic acid (PSA) on neural cell adhesion molecules. This antibody, produced through a hybridoma technique, demonstrates high specificity and sensitivity towards ST8SIA3 in human samples, making it ideal for use in various research applications such as immunohistochemistry and flow cytometry.ST8SIA3 plays a crucial role in neuronal development and synaptic plasticity, making it a target of interest in neurobiology and neurodegenerative disease research.
Dysregulation of ST8SIA3 has been implicated in conditions such as Alzheimer's disease and schizophrenia, highlighting its importance in neurological function. By utilizing the ST8SIA3 Monoclonal Antibody, researchers can accurately detect and study ST8SIA3 expression in cells and tissues, aiding in the advancement of understanding of its role in neuronal processes and disease pathology.
ST8SIA3: May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. Belongs to the glycosyltransferase 29 family.Protein type: Membrane protein, integral; Transferase; EC 2.4.99.-; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio seriesChromosomal Location of Human Ortholog: 18q21.31Cellular Component: Golgi membrane; integral to Golgi membraneMolecular Function: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity; sialic acid bindingBiological Process: glycosphingolipid biosynthetic process; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; glycoprotein metabolic process; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; N-glycan processing; post-translational protein modification; oligosaccharide metabolic process; ganglioside biosynthetic process
UniProt Protein Details:
NCBI Summary:
ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]
