The Trim6 Antibody (PACO12923) is a highly specific and reliable tool for researchers studying Trim6, a protein involved in the regulation of immune responses and intracellular signaling pathways. This polyclonal antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.Trim6, also known as an E3 ubiquitin ligase, plays a crucial role in the ubiquitination and degradation of target proteins involved in immune response pathways. By targeting specific proteins for degradation, Trim6 can modulate immune signaling cascades and influence inflammatory responses.
Understanding the function of Trim6 is essential for uncovering its potential role in diseases such as cancer, infectious diseases, and autoimmune disorders.With its high specificity and sensitivity, the Trim6 Antibody is an invaluable tool for researchers seeking to investigate the role of Trim6 in various cellular processes and disease states. Its ability to detect Trim6 protein levels in different cell types makes it ideal for immunology and cancer research studies. Unlock the potential of Trim6 and explore its impact on immune regulation with the use of this reliable antibody.
TRIM6: is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 11p15.4Cellular Component: cytoplasmMolecular Function: protein binding; protein binding, bridging; protein kinase bindingBiological Process: negative regulation of viral genome replication; positive regulation of cytokine secretion during immune response; positive regulation of defense response to virus by host; positive regulation of peptidyl-serine phosphorylation; response to lipopolysaccharide
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
