The TRO Antibody (PAC062391) is a high-quality polyclonal antibody specifically designed for research involving TRO, a protein implicated in various cellular processes and pathways. This antibody, raised in rabbits, has shown high reactivity with human samples and is validated for use in a variety of applications including Western blot and immunohistochemistry.TRO, also known as tumor necrosis factor receptor superfamily member 19 (TNFRSF19), is involved in the regulation of cell survival, proliferation, and apoptosis. It plays a critical role in various physiological and pathological processes, making it a valuable target for research in cancer, developmental biology, and immunology.
The TRO Antibody binds specifically to the TRO protein, allowing for accurate detection and analysis in different cell types and tissues.Understanding the function and regulation of TRO is essential for advancing our knowledge of cancer biology and other diseases. The TRO Antibody provides researchers with a reliable tool for studying TRO expression and function, opening up new avenues for exploration and discovery in the fields of oncology and cell biology.
Immunofluorescence staining of Hela cells with PACO62391 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.
Synonyms:
Trophinin (MAGE-D3 antigen), TRO, KIAA1114 MAGED3
UniProt Protein Function:
TRO: Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesionChromosomal Location of Human Ortholog: Xp11.22-p11.21Cellular Component: cytoplasm; integral to plasma membrane; nucleus; plasma membraneMolecular Function: protein bindingBiological Process: embryo implantation; homophilic cell adhesion; negative regulation of cell growth
UniProt Protein Details:
NCBI Summary:
This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
