Description
ZBTB7B Antibody (PACO13293)
The ZBTB7B Polyclonal Antibody (PAC013293) is a valuable tool for researchers studying ZBTB7B, a transcription factor involved in various cellular processes, including cell proliferation, differentiation, and tumorigenesis. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards ZBTB7B in human samples, making it suitable for use in Western blot and immunohistochemistry applications.ZBTB7B, also known as Pokemon, plays a key role in regulating the expression of genes associated with cell cycle progression and oncogenesis.
Dysregulation of ZBTB7B has been linked to the development and progression of various cancers, making it a potential therapeutic target in cancer research. By utilizing the ZBTB7B Polyclonal Antibody, researchers can investigate the function and expression of ZBTB7B in different cell types and disease states, advancing our understanding of its role in cancer biology.
| Antibody Name: | ZBTB7B Antibody (PACO13293) |
| Antibody SKU: | PACO13293 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human ZBTB7B |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | zinc finger and BTB domain containing 7B;ZBTB7B;DKFZp686G01254;THPOK;ZBTB15;ZFP67;ZNF857B;c-Krox;hcKrox ; |
| UniProt Protein Function: | ZBTB7B: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; metal ion binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; multicellular organismal development; ectoderm development; cell differentiation |
| NCBI Summary: | This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | O15156 |
| NCBI GenInfo Identifier: | 51316943 |
| NCBI Gene ID: | 51043 |
| NCBI Accession: | O15156.2 |
| UniProt Secondary Accession: | O15156,Q68DR2, Q96EP2, B4E3K5, D3DV83, J3KQQ3, |
| UniProt Related Accession: | O15156 |
| Molecular Weight: | 539 |
| NCBI Full Name: | Zinc finger and BTB domain-containing protein 7B |
| NCBI Synonym Full Names: | zinc finger and BTB domain containing 7B |
| NCBI Official Symbol: | ZBTB7BÂ Â |
| NCBI Official Synonym Symbols: | CKROX; THPOK; ZFP67; ZBTB15; ZFP-67; c-KROX; hcKROX; ZNF857BÂ Â |
| NCBI Protein Information: | zinc finger and BTB domain-containing protein 7B; zinc finger protein 857B; zinc finger protein Th-POK; zinc finger protein 67 homolog; zinc finger and BTB domain containing 15; T-helper-inducing POZ/Krueppel-like factor; krueppel-related zinc finger protein cKrox |
| UniProt Protein Name: | Zinc finger and BTB domain-containing protein 7B |
| UniProt Synonym Protein Names: | Krueppel-related zinc finger protein cKrox; hcKrox; T-helper-inducing POZ/Krueppel-like factor; Zinc finger and BTB domain-containing protein 15; Zinc finger protein 67 homolog; Zfp-67; Zinc finger protein 857B; Zinc finger protein Th-POK |
| Protein Family: | Zinc finger and BTB domain-containing protein |
| UniProt Gene Name: | ZBTB7BÂ Â |
| UniProt Entry Name: | ZBT7B_HUMAN |
