The AATK Polyclonal Antibody (PACO20089) is a powerful tool for researchers studying the AATK protein, a crucial player in multiple cellular processes and signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.AATK, also known as apoptosis-associated tyrosine kinase, is involved in regulating cell survival, differentiation, and growth. Its diverse functions make it an intriguing target for research in various fields, including neuroscience, cancer biology, and developmental biology.
By targeting and detecting the AATK protein, researchers can gain insights into its role in these processes and potentially uncover new therapeutic targets for diseases.With its reliability and specificity, the AATK Polyclonal Antibody is a valuable tool for researchers looking to explore the functions and interactions of the AATK protein in different cellular contexts. Whether studying neuronal development, cancer progression, or other biological processes, this antibody enables precise detection and analysis, paving the way for new discoveries in molecular biology and medicine.
Antibody Name:
AATK Antibody (PACO20089)
Antibody SKU:
PACO20089
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human AATK
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20089(AATK Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20089(AATK Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:
apoptosis-associated tyrosine kinase
UniProt Protein Function:
Lmr1: a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported.Protein type: Membrane protein, integral; EC 2.7.11.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Lmr familyChromosomal Location of Human Ortholog: 17q25.3
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
