The AATK Polyclonal Antibody (PAC020090) is a high-quality antibody designed for research involving AATK, a protein known for its role in various cellular functions, including neuronal development and cell growth regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the AATK protein, allowing for accurate detection and analysis in a variety of cell types.AATK, also known as apoptosis-associated tyrosine kinase, is a crucial player in cell signaling pathways that regulate cell survival and apoptosis.
Its importance in cellular processes makes it a key target for research in areas such as neuroscience, cancer, and developmental biology. Studying the function of AATK can provide valuable insights into diseases related to abnormal cell growth and survival, making this antibody an essential tool for scientists in these fields.
Antibody Name:
AATK Antibody (PACO20090)
Antibody SKU:
PACO20090
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human AATK
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20090(AATK Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20090(AATK Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:
apoptosis-associated tyrosine kinase
UniProt Protein Function:
Lmr1: a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported.Protein type: Membrane protein, integral; EC 2.7.11.1; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Lmr familyChromosomal Location of Human Ortholog: 17q25.3
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
