The ABCA13 Polyclonal Antibody (PACO3551) is ideal for researchers studying the ABCA13 protein, a member of the ATP-binding cassette (ABC) transporter family known for its role in lipid transport and cellular homeostasis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.ABCA13, a large transmembrane protein, has been implicated in various cellular processes, including lipid metabolism, drug resistance, and neurodegenerative diseases. The ABCA13 Polyclonal Antibody binds specifically to ABCA13, allowing for its detection and analysis in different cell types.
Its high reactivity and specificity make it a valuable tool for researchers studying lipid transport, neurobiology, and related fields.Understanding the function and regulation of ABCA13 is essential for uncovering its role in health and disease, such as Alzheimer's disease, atherosclerosis, and cancer. The ABCA13 Polyclonal Antibody provides a reliable means for investigating the expression and activity of ABCA13 in various experimental settings, contributing to advancements in biomedical research and potential therapeutic strategies.
Antibody Name:
ABCA13 Antibody
Antibody SKU:
PACO03551
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human ABCA13.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ABCA13; ATP-binding cassette sub-family A member 13
UniProt Protein Function:
ABCA13: In human, the ATP-binding cassette (ABC) family of transmembrane transporters has at least 48 genes and 7 gene subfamilies. This gene is a member of ABC gene subfamily A (ABCA). Genes within the ABCA family typically encode several thousand amino acids. Like other ABC transmembrane transporter proteins, this protein has 12 or more transmembrane alpha-helix domains that likely arrange to form a single central chamber with multiple substrate binding sites. It is also predicted to have two large extracellular domains and two nucleotide binding domains as is typical for ABCA proteins. Alternative splice variants have been described but their biological validity has not been demonstrated.[provided by RefSeq, Mar 2009]Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 7p12.3Cellular Component: integral to membraneMolecular Function: transporter activity; ATPase activity; ATP bindingBiological Process: transport; metabolic process
UniProt Protein Details:
NCBI Summary:
In human, the ATP-binding cassette (ABC) family of transmembrane transporters has at least 48 genes and 7 gene subfamilies. This gene is a member of ABC gene subfamily A (ABCA). Genes within the ABCA family typically encode several thousand amino acids. Like other ABC transmembrane transporter proteins, this protein has 12 or more transmembrane alpha-helix domains that likely arrange to form a single central chamber with multiple substrate binding sites. It is also predicted to have two large extracellular domains and two nucleotide binding domains as is typical for ABCA proteins. Alternative splice variants have been described but their biological validity has not been demonstrated.[provided by RefSeq, Mar 2009]
ATP-binding cassette, sub-family A (ABC1), member 13
NCBI Official Symbol:
ABCA13Â Â
NCBI Official Synonym Symbols:
NCBI Protein Information:
ATP-binding cassette sub-family A member 13; ATP binding cassette transporter A13; ATP-binding cassette sub-family A member 13 variant 2; ATP-binding cassette sub-family A member 13 variant 3
