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ABCC8 Rabbit Polyclonal Antibody (CAB8456)

SKU:
CAB8456
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€139 - €419
Frequently bought together:

Description

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Product Name:ABCC8 Rabbit Polyclonal Antibody
SKU:CAB8456
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human ABCC8 (NP_000343.2).
Sequence:TIRI PRGQ LTMI VGQV GCGK SSLL LAAL GEMQ KVSG AVFW SSLP DSEI GEDP SPER ETAT DLDI RKRG PVAY ASQK PWLL NATV EENI IFES PFNK QRYK MVIE ACSL QPDI DILP HGDQ TQIG ERGI NLSG GQRQ RISV ARAL YQHA NVVF LDDP FSAL DIHL SDHL MQAG ILEL LRDD KRTV VLVT HKLQ YLPH ADWI IAMK DGTI QREG TLKD FQRS ECQL FEHW KTLM NRQD QELE KETV TERK ATEP PQGL SRAM SSRD GLLQ DEEE EEEE AAES EEDD NLSS MLHQ RAEI PWRA C
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; PNDM3; TNDM2; SUR1delta2; ABCC8
Positive Sample:Mouse pancreas
Conjugate:Unconjugated
Cellular Localization:Membrane, Multi-pass membrane protein.
Calculated MW:177kDa
Observed MW:177kDa

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations in the ABCC8 gene and deficiencies in the encoded protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.

Purification Method:Affinity purification
Gene ID:6833
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of mouse pancreas, using ABCC8 antibody (CAB8456) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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