The ABCD4 Polyclonal Antibody (CAB17523) is a powerful tool for researchers studying the ABCD4 protein, an essential component of peroxisomal lipid metabolism. This antibody, derived from rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications. By binding to the ABCD4 protein, this antibody enables precise detection and analysis in a variety of cell types, particularly in studies focused on lipid metabolism, peroxisomal biology, and related diseases.ABCD4 is a key player in peroxisomal fatty acid oxidation and phytanic acid metabolism, processes critical for cellular energy production and lipid homeostasis.
Dysregulation of ABCD4 function is associated with severe peroxisomal disorders such as Zellweger syndrome spectrum. Research into the molecular mechanisms and regulation of ABCD4 is crucial for developing targeted therapies for these life-threatening conditions.Overall, the ABCD4 Polyclonal Antibody (CAB17523) offers researchers a reliable tool for investigating the functions and dysregulation of the ABCD4 protein, paving the way for advancements in peroxisomal biology and potential therapeutic interventions for related disorders.
Product Name:
ABCD4 Rabbit Polyclonal Antibody
SKU:
CAB17523
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human ABCD4 (NP_005041.1).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in several protein-coding and non-protein-coding variants.
Purification Method:
Affinity purification
Gene ID:
5826
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from MCF7 cells, using ABCD4 Rabbit pAb (CAB17523) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
