Description
ACIN1 Antibody (PACO19043)
The ACIN1 Polyclonal Antibody (PAC019043) is a valuable tool for researchers studying ACIN1, a protein involved in apoptosis and DNA damage response pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting ACIN1 in human samples, making it ideal for use in Western blot applications. By binding to the ACIN1 protein, this antibody enables researchers to analyze its expression and function in various cell types, facilitating studies in cancer biology and genetics.
ACIN1 is a key player in apoptosis, serving as a regulator of caspase activation and DNA fragmentation during programmed cell death. Its role in DNA damage response pathways highlights its importance in maintaining genome stability and preventing the development of cancer. By investigating the function of ACIN1, researchers can gain insights into the mechanisms underlying cancer progression and potential therapeutic targets for treating this disease.
| Antibody Name: | ACIN1 Antibody (PACO19043) |
| Antibody SKU: | PACO19043 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human ACIN1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO19043(ACIN1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19043(ACIN1 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Synonyms: | apoptotic chromatin condensation inducer 1 |
| UniProt Protein Function: | acinus: an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA splicing; Spliceosome; Apoptosis Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: nucleoplasm; cytoplasm; nucleolus; plasma membrane; nuclear speck; cytosol; nucleus Molecular Function:protein binding; enzyme binding; nucleic acid binding; ATPase activity; nucleotide binding Biological Process: positive regulation of monocyte differentiation; negative regulation of nuclear mRNA splicing, via spliceosome; apoptosis; positive regulation of apoptosis; RNA splicing; erythrocyte differentiation; mRNA processing; apoptotic chromosome condensation; cell structure disassembly during apoptosis |
| NCBI Summary: | Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9UKV3 |
| NCBI GenInfo Identifier: | 308153407 |
| NCBI Gene ID: | 22985 |
| NCBI Accession: | Q9UKV3.2 |
| UniProt Secondary Accession: | Q9UKV3,O75158, Q9UG91, Q9UKV1, Q9UKV2, B2RTT4, D3DS45 |
| UniProt Related Accession: | Q9UKV3 |
| Molecular Weight: | 1341 |
| NCBI Full Name: | Apoptotic chromatin condensation inducer in the nucleus |
| NCBI Synonym Full Names: | apoptotic chromatin condensation inducer 1 |
| NCBI Official Symbol: | ACIN1Â Â |
| NCBI Official Synonym Symbols: | ACN; ACINUS; fSAP152Â Â |
| NCBI Protein Information: | apoptotic chromatin condensation inducer in the nucleus; functional spliceosome-associated protein 152 |
| UniProt Protein Name: | Apoptotic chromatin condensation inducer in the nucleus |
| Protein Family: | Apoptotic chromatin condensation inducer in the nucleus |
| UniProt Gene Name: | ACIN1Â Â |
| UniProt Entry Name: | ACINU_HUMAN |
