The ACOT11 Polyclonal Antibody (PACO7561) is a valuable tool for researchers studying ACOT11, an enzyme involved in lipid metabolism and mitochondrial function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the ACOT11 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for investigations in metabolism, energy regulation, and related disease pathways.ACOT11, also known as acyl-CoA thioesterase 11, plays a crucial role in the breakdown of fatty acids and the regulation of lipid signaling pathways within cells.
Dysregulation of ACOT11 has been implicated in various metabolic disorders, making it a promising target for therapeutic intervention. By studying the function and expression of ACOT11, researchers can gain insight into the mechanisms underlying metabolic diseases such as obesity, diabetes, and cardiovascular disorders, paving the way for the development of novel treatment strategies.
ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.2.-Chromosomal Location of Human Ortholog: 1p32.3Cellular Component: cytoplasmMolecular Function: acyl-CoA hydrolase activity; lipid bindingBiological Process: response to temperature stimulus; response to cold; fatty acid metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
