The ACPT Polyclonal Antibody (PAC018647) is a valuable tool for researchers studying the ACPT protein, an enzyme involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ACPT protein, this antibody allows for the detection and analysis of ACPT in different cell types, making it ideal for studies in biochemistry and cell biology.
ACPT, also known as acid phosphatase, is a crucial enzyme that plays a role in maintaining cellular homeostasis by regulating the hydrolysis of various phosphomonoesters. Its involvement in these processes makes it an attractive target for research into diseases like metabolic disorders and certain cancers. Understanding the function of ACPT is essential for developing therapies that target this enzyme for potential treatment options in these disease contexts.
Antibody Name:
ACPT Antibody (PACO18647)
Antibody SKU:
PACO18647
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ACPT
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18647(ACPT Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18647(ACPT Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
acid, phosphatases are enzymes capable of hydrolyzing orthophosphoric acid, esters in an acid, medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid, phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Synonyms:
acid, phosphatase, testicular
UniProt Protein Function:
ACPT: Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage. Belongs to the histidine acid phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cofactor and Vitamin Metabolism - riboflavin; Phosphatase (non-protein); Membrane protein, integral; EC 3.1.3.2; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 19q13.4Cellular Component: integral to membraneMolecular Function: acid phosphatase activityBiological Process: dephosphorylation
UniProt Protein Details:
NCBI Summary:
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
