The ACSM5 Polyclonal Antibody (PAC015272) is a valuable tool for researchers studying the adipocytokine, ACSM5, which plays a key role in metabolic regulation and energy homeostasis. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ACSM5 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in metabolic disorders and obesity research.ACSM5, also known as acyl-CoA synthetase medium-chain family member 5, is involved in the activation of medium-chain fatty acids for energy production and lipid metabolism.
Dysregulation of ACSM5 has been linked to metabolic diseases such as obesity, type 2 diabetes, and fatty liver disease, making it a promising target for therapeutic interventions. By unraveling the functions of ACSM5, researchers can gain valuable insights into the mechanisms underlying these diseases and develop targeted treatment strategies for improved patient outcomes.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15272(ACSM5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal kidney tissue, Primary antibody: PACO15272(ACSM5 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15272(ACSM5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The acyl-CoA synthetase medium-chain (ACSM) family is comprised of ACSM1, ACSM2A, ACSM2B, ACSM3, ACSM4 and ACSM5, which encode for enzymes catalyzing the activation of medium-chain length fatty acid, ACSM5 is a 579 amino acid, protein has a broad substrate specificity and utilizes magnesium or manganese as a cofactor. ACSM5 is expressed in kidney and liver.
Synonyms:
acyl-CoA synthetase medium-chain family member 5
UniProt Protein Function:
ACSM5: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Carbohydrate Metabolism - butanoate; Mitochondrial; EC 6.2.1.2; LigaseChromosomal Location of Human Ortholog: 16p12.3
