Description
ACTC1/ACTG1/ACTG2/ACTA1 Antibody (PACO04845)
The ACTC1/ACTG1/ACTG2/ACTA1 Antibody (PACO04845) is a polyclonal antibody designed for research involving the actin family of proteins, including ACTC1, ACTG1, ACTG2, and ACTA1. These proteins play key roles in cell structure, movement, and contraction, making them essential for a wide range of cellular processes.This antibody, raised in rabbits, is highly specific and reacts strongly with human samples, making it ideal for use in Western blot applications. It binds to the various actin proteins, enabling researchers to detect and analyze their expression levels in different cell types and tissues.
This makes it a valuable tool for studies in cell biology, neuroscience, and muscle research.The actin family of proteins is involved in a variety of cellular functions, including cell division, migration, and signaling. Dysregulation of these proteins has been implicated in diseases such as cancer, heart disease, and neurological disorders. By studying the activity and expression of ACTC1, ACTG1, ACTG2, and ACTA1, researchers can gain valuable insights into the mechanisms underlying these conditions, potentially leading to the development of new therapeutic strategies.
| Antibody Name: | ACTC1/ACTG1/ACTG2/ACTA1 Antibody |
| Antibody SKU: | PACO04845 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human Actin-alpha/gamma around the non-phosphorylation site of Y55/53. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ACTC1; ACTC; Actin; alpha cardiac muscle 1; Alpha-cardiac actin; ACTG1; ACTB; ACTG; Actin, cytoplasmic 2; Gamma-actin; ACTG2; ACTA3; ACTL3; ACTSG; Actin, gamma-enteric smooth muscle; Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin; |
| UniProt Protein Function: | ACTC1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Contractile; Cell development/differentiation; Motility/polarity/chemotaxis; Myosin-binding Chromosomal Location of Human Ortholog: 15q14 Cellular Component: actin filament; cytoplasm; cytosol; extracellular space; filopodium; focal adhesion; I band; lamellipodium; membrane; sarcomere Molecular Function:ATP binding; ATPase activity; myosin binding Biological Process: actin filament-based movement; actin-myosin filament sliding; actomyosin structure organization and biogenesis; apoptosis; cardiac muscle morphogensis; cardiac myofibril assembly; heart contraction; muscle filament sliding; muscle thin filament assembly Disease: Atrial Septal Defect 5; Cardiomyopathy, Dilated, 1r; Cardiomyopathy, Familial Hypertrophic, 11 |
| NCBI Summary: | Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P68032 |
| NCBI GenInfo Identifier: | 54036697 |
| NCBI Gene ID: | 70 |
| NCBI Accession: | P68032.1 |
| UniProt Secondary Accession: | P68032,P04270, |
| UniProt Related Accession: | P68032 |
| Molecular Weight: | 42,019 Da |
| NCBI Full Name: | Actin, alpha cardiac muscle 1 |
| NCBI Synonym Full Names: | actin, alpha, cardiac muscle 1 |
| NCBI Official Symbol: | ACTC1Â Â |
| NCBI Official Synonym Symbols: | ACTC; ASD5; CMD1R; CMH11; LVNC4Â Â |
| NCBI Protein Information: | actin, alpha cardiac muscle 1 |
| UniProt Protein Name: | Actin, alpha cardiac muscle 1 |
| UniProt Synonym Protein Names: | Alpha-cardiac actin |
| Protein Family: | Actin |
| UniProt Gene Name: | ACTC1Â Â |
| UniProt Entry Name: | ACTC_HUMAN |
