The ACTL7A Polyclonal Antibody (PACO42698) is a valuable tool for researchers studying ACTL7A, a protein involved in chromatin remodeling and gene regulation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in immunohistochemistry and Western blot applications. It specifically binds to the ACTL7A protein, allowing for accurate detection and analysis in various cell types and tissues.ACTL7A plays a key role in the regulation of gene expression and chromatin organization, making it a critical target for research in the fields of epigenetics, cancer biology, and developmental biology.
Dysregulation of ACTL7A has been implicated in various diseases, including cancer and neurological disorders, highlighting its potential as a therapeutic target. By studying the function of ACTL7A, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel treatment strategies.
Western blot. All lanes: ACTL7A antibody at 2µg/ml + Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 49 kDa. Observed band size: 49 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO42698 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human melanoma using PACO42698 at dilution of 1:100.
Background:
Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer.
Synonyms:
Actin-like protein 7A (Actin-like-7-alpha), ACTL7A
UniProt Protein Function:
AL7A: an actin-related protein (ARP). Shares significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. Its gene (ACTL7A), and a related gene, ACTL7B, are intronless. Expressed in a wide variety of adult tissues, however, its exact function is not known.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 9q31Cellular Component: male germ cell nucleus; Golgi apparatus; protein complex; cytoskeleton; cytoplasm; nucleusMolecular Function: structural constituent of cytoskeleton
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]
