The ADAM8 Antibody (CAB10497) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it an excellent choice for Western blot applications.ADAM8, a member of the ADAM (a disintegrin and metalloproteinase) family, is known for its role in proteolytic processing of cell surface proteins and extracellular matrix components. Its dysregulation has been implicated in various diseases, including cancer, inflammation, and asthma. By targeting ADAM8 with this polyclonal antibody, researchers can detect and analyze protein levels in different cell types, shedding light on its function and potential as a therapeutic target.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
ADAM8 Antibody
SKU:
CAB10497
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
MS2, CD156, CD156a, ADAM8
Positive Sample:
NIH/3T3, Raji, C6
Cellular Localization:
Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
89kDa
Observed MW:
100kDa
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
101
RRID
AB_2758046
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ADAM8 Rabbit pAb (CAB10497) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 180s.
