The ADAMTS1 Antibody (PAC020983) is a powerful tool for researchers studying the ADAMTS1 protein, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family known for its involvement in extracellular matrix remodeling and angiogenesis. This polyclonal antibody, produced in rabbits, has high specificity for ADAMTS1 and is validated for use in various experimental applications, including Western blotting.ADAMTS1 is a key player in processes such as embryonic development, wound healing, and tissue repair. Dysregulation of ADAMTS1 has been implicated in various diseases, including cancer, arthritis, and cardiovascular disorders.
By targeting ADAMTS1 with this antibody, researchers can gain insights into its function and potential therapeutic applications in these conditions.This antibody will enable the detection and analysis of ADAMTS1 in different cell types and tissues, making it an indispensable tool for studies in molecular biology, cell biology, and pathology. Its high reactivity with human samples further enhances its utility in translational research aimed at understanding and targeting ADAMTS1 in disease contexts.
Antibody Name:
ADAMTS1 Antibody (PACO20983)
Antibody SKU:
PACO20983
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human ADAMTS1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20983(ADAMTS1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 1
UniProt Protein Function:
ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
UniProt Protein Details:
Protein type:Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted
Molecular Function:heparin binding; metalloendopeptidase activity; metallopeptidase activity; zinc ion binding
Biological Process: integrin-mediated signaling pathway; kidney development; negative regulation of cell proliferation; ovulation from ovarian follicle; proteolysis
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
