The ADAMTS15 Antibody (PACO19059) is a key tool for researchers studying ADAMTS15, a member of the ADAMTS family of proteins involved in extracellular matrix remodeling and tissue homeostasis. This antibody, produced through immunization of rabbits, is highly specific for human samples and has been validated for use in Western blot applications.ADAMTS15, a metalloprotease enzyme, is known to play a role in various pathological processes, including inflammation, angiogenesis, and tumor progression. Research into the function of ADAMTS15 is particularly crucial in understanding its potential as a biomarker or therapeutic target in conditions like cancer, cardiovascular diseases, and arthritis.
By utilizing the ADAMTS15 Antibody in their experiments, scientists can gain valuable insights into the expression and activity of ADAMTS15 in different cell types and tissues. This antibody enables precise detection and analysis of ADAMTS15 protein levels, aiding in the exploration of its involvement in disease mechanisms and potential treatment strategies.
Antibody Name:
ADAMTS15 Antibody (PACO19059)
Antibody SKU:
PACO19059
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ADAMTS15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: PACO19059(ADAMTS15 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 minutes.
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 15
UniProt Protein Function:
ADAMTS15: Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.24.-; Protease; Extracellular matrixChromosomal Location of Human Ortholog: 11q25
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
