The ADAMTS16 Polyclonal Antibody (PACO19061) is an essential tool for researchers studying the ADAMTS16 protein, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.ADAMTS16 is known to play a crucial role in various physiological processes, including extracellular matrix remodeling, tissue development, and inflammation. Its dysregulation has been implicated in diseases such as cancer, arthritis, and cardiovascular disorders, making it a promising therapeutic target.
By using the ADAMTS16 Polyclonal Antibody, researchers can detect and analyze the ADAMTS16 protein in different cell types, providing valuable insights into its function and potential involvement in disease pathology. This antibody is a valuable asset for studies in molecular biology, cell biology, and pathology, enabling researchers to deepen their understanding of ADAMTS16's role in health and disease.
Antibody Name:
ADAMTS16 Antibody (PACO19061)
Antibody SKU:
PACO19061
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ADAMTS16
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: PACO19061(ADAMTS16 Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 minutes.
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS18, another family member.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 16
UniProt Protein Function:
ADAMTS16: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted, signal peptideChromosomal Location of Human Ortholog: 5p15Cellular Component: proteinaceous extracellular matrixMolecular Function: zinc ion binding; metalloendopeptidase activityBiological Process: ureteric bud branching; proteolysis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS18, another family member. [provided by RefSeq, Jul 2008]
A disintegrin and metalloproteinase with thrombospondin motifs 16 preproprotein
NCBI Synonym Full Names:
ADAM metallopeptidase with thrombospondin type 1 motif, 16
NCBI Official Symbol:
ADAMTS16Â Â
NCBI Official Synonym Symbols:
ADAMTS16s Â
NCBI Protein Information:
A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM-TS 16; ADAM-TS16; ADAMTS-16; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16
UniProt Protein Name:
A disintegrin and metalloproteinase with thrombospondin motifs 16
UniProt Synonym Protein Names:
Protein Family:
A disintegrin and metalloproteinase with thrombospondin motifs
