The ADAMTS17 Polyclonal Antibody (PACO3573) is a valuable tool for researchers studying ADAMTS17, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteins that play critical roles in extracellular matrix remodeling and cell signaling. This antibody, raised in rabbits, has been rigorously validated for use in various research applications, including Western blot analysis, immunofluorescence, and immunohistochemistry. It specifically binds to the ADAMTS17 protein, enabling precise detection and analysis in a variety of cell and tissue samples.
ADAMTS17 has been implicated in a wide range of biological processes, including angiogenesis, wound healing, and cartilage development. Dysregulation of ADAMTS17 expression has been linked to various diseases, making it a promising target for therapeutic interventions. Research using the ADAMTS17 Polyclonal Antibody can provide valuable insights into the molecular mechanisms underlying these conditions and aid in the development of novel treatments.
Antibody Name:
ADAMTS17 Antibody
Antibody SKU:
PACO03573
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human ADAMTS-17.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ADAMTS17; A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM-TS 17; ADAM-TS17; ADAMTS-17
UniProt Protein Function:
ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.24.-; Secreted; Secreted, signal peptide; Protease; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q24Disease: Weill-marchesani-like Syndrome
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
