Description
ADCY8 Antibody (PACO23305)
The ADCY8 Polyclonal Antibody (PAC023305) is a valuable tool for researchers studying ADCY8, an enzyme that plays a key role in cellular signaling pathways. This antibody, generated in rabbits, is highly specific to human samples and is suitable for use in Western blotting and immunohistochemistry applications. By binding to ADCY8, the antibody enables researchers to detect and analyze the enzyme in a variety of cell types, making it an essential component for studies in cell signaling and disease mechanisms.ADCY8, also known as adenylate cyclase 8, is involved in the production of the second messenger molecule cyclic AMP (cAMP), which regulates various cellular processes including gene expression, metabolism, and cell growth.
Dysregulation of ADCY8 has been associated with neurological disorders, cardiovascular diseases, and cancer, making it a target of interest for drug development and therapeutic interventions. By investigating the functions of ADCY8, researchers can gain insights into the underlying mechanisms of these diseases and identify potential treatment strategies.
| Antibody Name: | ADCY8 Antibody (PACO23305) |
| Antibody SKU: | PACO23305 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human ADCY8. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ADCY8 antibody. |
 | Immunofluorescence analysis of A549 cells, using ADCY8 antibody. |
| Background: | This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence By similarity. |
| Synonyms: | Adenylate cyclase type 8; EC 4.6.1.1; Adenylate cyclase type VIII; ATP pyrophosphate-lyase 8; Adenylyl cyclase 8 |
| UniProt Protein Function: | ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Transporter; Membrane protein, multi-pass; Lyase; Membrane protein, integral; Transporter, aquaporin family; Adenylyl cyclase; EC 4.6.1.1 Chromosomal Location of Human Ortholog: 8q24 Cellular Component: membrane; integral to membrane; plasma membrane Molecular Function:metal ion binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; learning and/or memory; long-term memory; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport |
| NCBI Summary: | Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008] |
| UniProt Code: | P40145 |
| NCBI GenInfo Identifier: | 729242 |
| NCBI Gene ID: | 114 |
| NCBI Accession: | P40145.1 |
| UniProt Related Accession: | P40145 |
| Molecular Weight: | 1251 |
| NCBI Full Name: | Adenylate cyclase type 8 |
| NCBI Synonym Full Names: | adenylate cyclase 8 (brain) |
| NCBI Official Symbol: | ADCY8Â Â |
| NCBI Official Synonym Symbols: | AC8; ADCY3; HBAC1Â Â |
| NCBI Protein Information: | adenylate cyclase type 8; adenylyl cyclase 8; ATP pyrophosphate-lyase 8; adenylyl cyclase-8, brain; adenylate cyclase type VIII; ca(2+)/calmodulin-activated adenylyl cyclase |
| UniProt Protein Name: | Adenylate cyclase type 8 |
| UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase |
| Protein Family: | Adenylate cyclase |
| UniProt Gene Name: | ADCY8Â Â |
| UniProt Entry Name: | ADCY8_HUMAN |
