The ADPRHL2 Polyclonal Antibody (PACO07625) is a valuable tool for researchers studying ADPRHL2, a key enzyme involved in ADP-ribosylation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the ADPRHL2 protein, this antibody enables accurate detection and analysis in a variety of cell types, facilitating research in fields such as molecular biology and cancer biology.ADPRHL2, also known as ADP-ribosylhydrolase-like 2, plays a crucial role in regulating cellular processes through its involvement in ADP-ribose metabolism.
Its function in maintaining genomic stability and DNA repair mechanisms has made it a target of interest in cancer research and therapeutic development. By gaining a better understanding of ADPRHL2 activity, researchers can potentially uncover new strategies for treating cancer and other diseases related to DNA damage and repair pathways.In summary, the ADPRHL2 Polyclonal Antibody (PACO07625) offers researchers a reliable tool for studying the function and regulation of the ADPRHL2 enzyme, providing valuable insights into cellular processes and potential therapeutic targets in various disease contexts.
ADP-ribosylhydrolase like 2;ADPRHL2;ARH3;FLJ20446 ;
UniProt Protein Function:
ADPRHL2: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Belongs to the ADP-ribosylglycohydrolase family.Protein type: Hydrolase; EC 3.2.1.143Chromosomal Location of Human Ortholog: 1p34.3Cellular Component: nucleoplasm
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
