The AGBL2 Polyclonal Antibody (PAC015041) is a valuable tool for researchers studying AGBL2, a protein involved in various cellular processes, including cell proliferation and differentiation. This antibody is raised in rabbits and is highly specific for human samples, making it a reliable choice for experiments involving Western blot analysis. By targeting the AGBL2 protein, researchers can effectively study its function in different cell types, making it ideal for investigations in cell biology and cancer research.
AGBL2, also known as ATP/GTP binding protein-like 2, is a key player in cell cycle regulation and has been implicated in cancer progression and metastasis. Understanding the role of AGBL2 in these processes is essential for developing targeted therapies for cancer and other related diseases. By using the AGBL2 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Antibody Name:
AGBL2 Antibody (PACO15341)
Antibody SKU:
PACO15341
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human AGBL2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15341(AGBL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15341(AGBL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Metallocarboxypeptidase that may play a role in the processing of tubulin. Knockdown of AGBL2 results in a failure of the cell to detyrosinate the C-terminal EEY region of α -tubulin and indicates that, it is a candidate for the long sought after tubulin tyrosine carboxypeptidase important in regulation of microtubule dynamics. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis and identify a novel area for therapeutic intervention.
Synonyms:
ATP/GTP binding protein-like 2
UniProt Protein Function:
AGBL2: Metallocarboxypeptidase that may play a role in the processing of tubulin. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.17.-; ProteaseChromosomal Location of Human Ortholog: 11p11.2Cellular Component: centriole; cytosolMolecular Function: zinc ion binding; metallocarboxypeptidase activityBiological Process: proteolysis
