Additionally, the CD300A Polyclonal Antibody (CAB10006) has been rigorously tested to ensure high specificity and sensitivity, providing reliable results for researchers studying immune regulation and related pathways. This antibody is a powerful tool for investigating the function and expression of CD300A in various experimental settings.In summary, the CD300A Polyclonal Antibody (CAB10006) from AssayGenie is a valuable resource for researchers interested in exploring the role of CD300A in immune regulation, inflammation, and disease.
With its high reactivity and specificity, this antibody enables precise detection and analysis of CD300A, facilitating groundbreaking research in immunology, cancer biology, and beyond.
Antibody Name:
AGO4 Antibody (PACO19148)
Antibody SKU:
PACO19148
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human AGO4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19148(AGO4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1.
Synonyms:
argonaute RISC catalytic component 4
UniProt Protein Function:
AGO4: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Belongs to the argonaute family. Ago subfamily.Protein type: Translation; Translation initiationChromosomal Location of Human Ortholog: 1p34Cellular Component: cytoplasm; cytosol; membraneMolecular Function: double-stranded RNA binding; miRNA binding; protein binding; single-stranded RNA bindingBiological Process: miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; miRNA-mediated gene silencing, production of miRNAs; mRNA catabolic process; phosphoinositide-mediated signaling; pre-microRNA processing; RNA secondary structure unwinding; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]
