The AGPAT9 Polyclonal Antibody (PACO06992) is a vital tool for researchers studying AGPAT9, an enzyme involved in glycerolipid biosynthesis. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards AGPAT9 in human samples and is validated for use in Western blot applications. By binding to the AGPAT9 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations in lipid metabolism and related fields.AGPAT9, also known as 1-acyl-sn-glycerol-3-phosphate acyltransferase 9, plays a crucial role in the biosynthesis of phospholipids and triglycerides, essential components of cell membranes and energy storage.
Dysregulation of AGPAT9 has been linked to various metabolic disorders, making it a promising target for research into obesity, diabetes, and cardiovascular diseases. Understanding the function of AGPAT9 is key to developing therapies aimed at modulating lipid metabolism and improving metabolic health.
AGPAT9: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
UniProt Protein Details:
Protein type:Transferase; Membrane protein, multi-pass; EC 2.3.1.51; EC 2.3.1.15; Membrane protein, integral
Biological Process: phosphatidic acid biosynthetic process; regulation of TOR signaling pathway; triacylglycerol biosynthetic process
NCBI Summary:
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
