The AGPAT9 Polyclonal Antibody (PAC019966) is a valuable tool for researchers studying the AGPAT9 protein, which plays a key role in lipid metabolism and cell signaling pathways. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for experiments involving Western blot analysis.AGPAT9, also known as 1-acyl-sn-glycerol-3-phosphate acyltransferase 9, is involved in the synthesis of phosphatidic acid, a vital lipid molecule that serves as a precursor for the production of various lipid species. Dysregulation of AGPAT9 has been linked to metabolic disorders and cancer progression, making it a promising target for therapeutic interventions.
By utilizing the AGPAT9 Polyclonal Antibody, researchers can effectively detect and analyze the expression of AGPAT9 in different cell types, aiding in the exploration of its molecular functions and potential implications in disease pathology.This antibody is a valuable tool for studying lipid metabolism, cell signaling, and potential therapeutic strategies targeting AGPAT9 in various disease contexts, providing valuable insights for drug development and personalized medicine approaches.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19966(AGPAT9 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 80 μg, Lane: Humna placenta tissue, Primary antibody: PACO19966(AGPAT9 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19966(AGPAT9 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the lysophosphatidic acid, acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid, in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms:
1-acylglycerol-3-phosphate O-acyltransferase 9
UniProt Protein Function:
AGPAT9: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
UniProt Protein Details:
Protein type:Transferase; Membrane protein, multi-pass; EC 2.3.1.51; EC 2.3.1.15; Membrane protein, integral
Biological Process: phosphatidic acid biosynthetic process; regulation of TOR signaling pathway; triacylglycerol biosynthetic process
NCBI Summary:
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
